“Chinese herbal medicine is a general term for traditional medicines in our country, which differs from Western medicine and proprietary Chinese medicine in that it does not have a standard usage manual. Our application of Chinese herbal medicine mainly refers to two national classics:“Pharmacopoeia of the People’s Republic of China” and “Clinical Use Guidelines of the Pharmacopoeia of the People’s Republic of China”.
This article will introduce Poria, making it convenient for searching and reference, and it is worth collecting.“
01—“Pharmacopoeia of the People’s Republic of China (2020 Edition)”
【Chinese Name】Poria【Pinyin】Fuling【English Name】PORIA【Introduction】This product is the dried sclerotium of the fungus Poria cocos (Schw) Wolf, belonging to the family Polyporaceae. It is harvested mainly from July to September. After excavation, the soil and sand are removed, and it is piled up to “sweat” before being spread out to dry until the surface is dry, then “sweated” again, repeatedly until wrinkles appear and most of the internal moisture is lost, then it is dried in the shade, referred to as “Fuling ge”; or fresh Poria is cut according to different parts and dried in the shade, referred to as “Fuling kuai” and “Fuling pian” respectively.【Characteristics】Fuling ge is spherical, oval, flat, or irregular clumps, varying in size. The outer skin is thin and rough, brown to dark brown, with obvious wrinkled texture. It is heavy, solid, with a granular fracture surface, some with cracks, the outer layer is light brown, the inside is white, and a few are light red, some contain pine roots. It has a faint odor, a bland taste, and is sticky when chewed.Fuling kuai is cut from peeled Poria, in cubic or thick slice form, varying in size. It is white, light red, or light brown.Fuling pian is cut from peeled Poria, in irregular thick slices, varying in thickness. It is white, light red, or light brown.【Identification】(1) The powder of this product is grayish-white. Irregular granules and branched clumps are colorless and gradually dissolve in water and chloroform solution. The mycelium is colorless or light brown, slender, slightly curved, branched, with a diameter of 3–8μm, some up to 16μm.(2) Take a small amount of the powder, add one drop of potassium iodide iodine test solution, and it shows deep red.(3) Take 1g of the powder, add 50ml of ether, treat with ultrasound for 10 minutes, filter, evaporate the filtrate, and dissolve the residue in 1ml of methanol to prepare the test solution. Take 1g of Poria as a control herb and prepare the control herb solution in the same way. According to thin-layer chromatography (General Rule 0502), apply 2μl of each of the two solutions on the same silica gel G thin-layer plate, using toluene-ethyl acetate-formic acid (20:5:0.5) as the developing agent, develop, remove, dry, and spray with a mixed solution of 2% vanillin-sulfuric acid solution-ethanol (4:1), heating at 105°C until the spots are clearly colored. In the test solution’s chromatogram, the main spots showing the same color as the control herb’s chromatogram appear at corresponding positions.【Examination】Moisture must not exceed 18.0% (General Rule 0832, Method 2).Total Ash must not exceed 2.0% (General Rule 2302).【Extractives】Determined by the method for determining alcohol-soluble extractives (General Rule 2201) using dilute ethanol as the solvent, must not be less than 2.5%.Herbal Pieces【Preparation】Take Fuling ge, soak, wash, moisten, steam slightly, promptly peel, cut into pieces or thick slices, and dry in the sun.【Characteristics】【Identification】【Examination】【Extractives】same as the medicinal material.【Nature and Taste】Sweet, bland, neutral. Enters the Heart, Lung, Spleen, and Kidney meridians.【Functions and Indications】Promotes urination and drains dampness, strengthens the Spleen, calms the mind. Used for edema, reduced urination, phlegm-damp dizziness, Spleen deficiency with poor appetite, loose stools, anxiety, and insomnia.【Dosage】10–15g.【Storage】Store in a dry place, protect from moisture.02—“Clinical Use Guidelines of the Pharmacopoeia of the People’s Republic of China (2015 Edition)”
【Chinese Name】Poria【Pinyin】Fuling【Introduction】This product is the dried sclerotium of the fungus Poria cocos (Schw) Wolf. It is mainly produced in Anhui, Yunnan, and Hubei. Harvested mainly from July to September, after excavation, the soil and sand are removed, and it is piled up to “sweat” before being spread out to dry until the surface is dry, then “sweated” again, repeatedly until wrinkles appear and most of the internal moisture is lost, then it is dried in the shade, referred to as “Fuling ge”, cut into blocks or thick slices; or fresh Poria is cut according to different parts and dried in the shade, referred to as “Fuling pi” and “Fuling kuai”. The best quality has a white, delicate cut surface and strong stickiness.【Nature and Taste】Sweet, bland, neutral. Enters the Heart, Lung, Spleen, and Kidney meridians.【Functions and Indications】Promotes urination and drains dampness, strengthens the Spleen, calms the mind. Used for edema, reduced urination, phlegm-damp dizziness, Spleen deficiency with poor appetite, loose stools, anxiety, and insomnia.【Effect Analysis】Poria is sweet and bland, sweet can tonify the middle, bland can drain and promote urination, good at promoting urination and draining dampness, making it a key herb for this purpose. Its properties are mild, tonifying without being harsh, draining without being forceful, suitable for treating various types of edema and urinary difficulties due to cold, heat, deficiency, or excess. It also strengthens the Spleen and drains dampness, preventing dampness accumulation and phlegm formation, making it a key herb for treating phlegm-related conditions such as dizziness and palpitations.Poria enters the Heart and Spleen meridians, can tonify the Spleen and assist in the generation of Qi and blood, nourishing the Heart, and has calming effects, commonly used for anxiety and insomnia, especially suitable for conditions caused by deficiency of the Heart and Spleen.【Compatibility Applications】1. Poria with Ze XiePoria has a neutral nature, can promote urination and expel pathogens; Ze Xie is cold in nature, with a stronger diuretic effect. When used together, Ze Xie benefits from Poria, promoting urination without harming Spleen Qi; Poria benefits from Ze Xie, enhancing its ability to promote urination and eliminate dampness. Suitable for edema due to water retention, urinary difficulties, and diarrhea.2. Poria with Ban XiaPoria tonifies the Spleen and promotes the transformation of water and dampness, preventing dampness accumulation and phlegm formation. Ban Xia warms and dries dampness, preventing the Spleen from being damp, thus preventing phlegm formation. Together, they can strengthen the Spleen, promote urination, dry dampness, transform phlegm, and calm the mind. Commonly used for Spleen deficiency with dampness retention, stomach disharmony, fullness in the chest, hiccups, vomiting, dizziness, palpitations, or cough with phlegm.3. Poria with Dang ShenPoria is sweet and bland, mainly promoting urination and draining dampness, with the ability to strengthen the Spleen and assist in transportation; Dang Shen is sweet and warm, best at tonifying the Spleen and benefiting Qi. Together, they enhance the Spleen tonifying and Qi benefiting effects; suitable for Spleen and stomach weakness with poor appetite and loose stools, edema due to Spleen deficiency with water retention, urinary difficulties, and diarrhea.4. Poria with Huang QiPoria is sweet and bland, with the ability to strengthen the Spleen and promote urination and drain dampness; Huang Qi is sweet and warm, excels at tonifying Qi and raising Yang, strengthening the Spleen, promoting urination, and reducing swelling. Together, they enhance the effects of strengthening the Spleen, benefiting Qi, promoting urination, and reducing swelling. Suitable for Spleen and stomach Qi deficiency with poor appetite, fatigue, and loose stools; edema, leukorrhea, and increased vaginal discharge due to Spleen deficiency.5. Poria with Zhu ShaPoria excels at tonifying the Spleen and calming the mind; Zhu Sha is good at clearing the Heart and calming the mind. Together, they enhance the calming effects, suitable for insomnia, palpitations, and forgetfulness.6. Poria with Fu ZiPoria is sweet and bland, excels at tonifying the Spleen and promoting urination and draining dampness; Fu Zi is acrid and hot, excels at warming the Kidney and assisting Yang. Together, they warm the Kidney and nourish the Earth, enhancing the warming Yang and promoting urination and draining dampness. Suitable for Spleen and Kidney Yang deficiency, edema in the limbs, and urinary difficulties.【Identification Applications】Poria, Poria Pi, and Fu ShenDifferent parts of Poria are used; Poria mainly enters the Qi aspect, excels at tonifying the Spleen, draining dampness, and calming the mind, suitable for urinary difficulties, edema, phlegm cough, nausea, diarrhea, nocturnal emissions, and urinary difficulties; Poria Pi is best at promoting the surface, good at draining water from the skin, mainly used for skin edema; Fu Shen excels at calming the mind, commonly used for heart deficiency, anxiety, forgetfulness, and insomnia.【Formula Examples】1. Wu Ling San(“Treatise on Febrile Diseases”)Ingredients: Zhu Ling, Ze Xie, Bai Zhu, Poria, Gui Zhi.Functions and Indications: Promotes urination and drains dampness, warms Yang and transforms Qi. Suitable for water retention due to bladder Qi dysfunction, urinary difficulties, mild headache, thirst, and in severe cases, vomiting upon water intake; or palpitations below the navel, vomiting foamy saliva, and dizziness; or shortness of breath and cough; or edema, diarrhea, white tongue coating, floating or rapid pulse.2. Ling Gui Zhu Gan Tang(“Essentials of Prescriptions from the Golden Cabinet”)Ingredients: Poria, Gui Zhi, Bai Zhu, Zhi Gan Cao.Functions and Indications: Warms Yang, transforms phlegm, strengthens the Spleen, and drains dampness. Suitable for phlegm-dampness due to insufficient Middle Yang, fullness in the chest and flanks, dizziness, palpitations, shortness of breath, white slippery tongue coating, and wiry slippery or tight pulse.3. Shen Ling Bai Zhu San(“Formulas from the Bureau of Harmonization”)Ingredients: Lotus seed flesh, Yi Yi Ren, Sha Ren, Jie Geng, Bai Bian Dou, Bai Fu Ling, Ren Shen, Gan Cao, Bai Zhu, Shan Yao.Functions and Indications: Benefits Qi, strengthens the Spleen, drains dampness, and stops diarrhea. Suitable for Spleen deficiency with excessive dampness, undigested food, fullness in the chest and abdomen, intestinal rumbling, diarrhea, fatigue, emaciation, pale yellow complexion, pale tongue with white greasy coating, and weak pulse.4. Gui Pi Tang(“Essentials of the Body”)Ingredients: Bai Zhu, Dang Gui, Bai Fu Ling, Huang Qi, Yuan Zhi, Longan flesh, Suan Zao Ren, Ren Shen, Mu Xiang, Zhi Gan Cao.Functions and Indications: Benefits Qi and nourishes blood, strengthens the Spleen, and nourishes the Heart. Suitable for deficiency of both Heart and Spleen Qi and blood, palpitations, forgetfulness, night sweats, fatigue, poor appetite, pale complexion, pale tongue, thin white coating, and weak pulse. Also suitable for Spleen not controlling blood, blood in stool, purpura, women’s menorrhagia, early menstruation with excessive flow, or continuous bleeding, pale tongue, and weak pulse.【Patent Medicine Examples】1. Ling Gui Ke Chuan Ning Capsules(“Clinical Use Guidelines for Chinese Patent Medicine Volume”2015 Edition)Ingredients: Poria, Gui Zhi, Jie Geng, Bitter Apricot Seed, Bai Zhu(roasted with bran), Chen Pi, Fa Ban Xia, Long Gu, Mu Li, Sheng Jiang, Da Zao, Gan Cao(honey-fried).Functions and Indications: Warms the Lung, transforms phlegm, stops cough, and calms wheezing. Used for cough with excessive phlegm, wheezing, and shortness of breath due to external wind-cold and phlegm-damp obstruction in the Lung; for acute and chronic bronchitis with the above symptoms.2. Xiao Er Zhi Xie An Granules(“Clinical Use Guidelines for Chinese Patent Medicine Volume”2015 Edition)Ingredients: Poria, Chen Pi, Mu Xiang(roasted), Sha Ren, Nutmeg(calcined), Red Stone Fat(calcined), Fu Long Gan.Functions and Indications: Strengthens the Spleen, harmonizes the stomach, and solidifies the intestines to stop diarrhea. Used for diarrhea due to Spleen and stomach weakness, symptoms include loose stools, poor appetite, and fatigue; for children with digestive disorders with the above symptoms.3. Hua Ji Oral Liquid(“Clinical Use Guidelines for Chinese Patent Medicine Volume”2015 Edition)Ingredients: Poria(peeled), Hai Piao Xiao, Roasted Chicken Inner Gold, Vinegar San Leng, Vinegar E Zhu, Hong Hua, Bing Lang, Lei Wan, He Shi, Shi Jun Zi Ren.Functions and Indications: Strengthens the Spleen, guides stagnation, transforms accumulation, and eliminates malnutrition. Used for malnutrition due to Spleen and stomach weakness, symptoms include yellowish complexion, emaciation, abdominal distension and pain, aversion to food or poor appetite, and irregular bowel movements.【Dosage】10–15g.【Caution】This product has a draining nature, so it should be used cautiously in cases of Yin deficiency without damp-heat, deficiency-cold with slippery sperm, or Qi deficiency with sinking.【Summary of Materia Medica】1. “Shen Nong’s Herbal Classic” “Mainly treats chest and flank counterflow Qi, anxiety, fear, palpitations, pain below the Heart, cold and heat, fullness, cough, dry mouth and tongue, promotes urination. Long-term use calms the soul, nourishes the spirit, prevents hunger, and prolongs life.2. “Record of Famous Physicians” “Stops thirst, promotes sleep, abdominal distension, urinary difficulties, clears the chest, regulates organ Qi, eliminates Kidney evil, nourishes Yin, benefits Qi strength, and protects the spirit and center.”3. “Discussion on Medicinal Properties” “Opens the appetite, stops vomiting, calms the mind. Mainly treats lung atrophy with phlegm obstruction, treats childhood seizures, abdominal distension, and fullness in women.”4. “Bencao Gangmu” “Nourishes the five labors and seven injuries, calms the fetus, warms the waist and knees, opens the mind, benefits intelligence, and stops forgetfulness.”【Chemical Components】Mainly contains polysaccharides, with the highest content of β-Poria polysaccharides; triterpenoid components: Poria acid, block Poria acid, tooth hole acid, etc.; sterol components: ergosterol, etc.; also contains proteins, fats, lecithin, adenine, etc.【Pharmacology and Toxicology】This product has diuretic, immune-regulating, anti-transplant rejection, anti-tumor, anti-aging, lipid-lowering, and liver-protective effects.1. Diuretic EffectIntravenous injection of Poria water decoction and alcohol precipitate at1.5 and 2.5g/kg in rabbits shows significant diuretic effects[1]. Rats given 150, 300, and 600mg/kg of Poria Pi ethanol extract by gavage can increase urine volume by 29%, 21%, and 42%, respectively; K+excretion decreased by 18%, 22%, and 27%, respectively; in the 600mg/kg group, urine Na+excretion increased by 14%. The main chemical components of the Poria Pi ethanol extract with diuretic effects are tetracyclic triterpenoids, including Poria acid, Zhu Ling acid C, dehydro Poria acid, 3-dehydro Poria acid, dehydro tooth hole acid, tooth hole acid, and dehydro tooth hole ketone acid.[2]Poria polysaccharides10mggavage for 4 weeks shows improvement in the rat model of kidney stones induced by ethylene glycol, with the area of calcium oxalate crystals in the kidneys significantly smaller than in the stone control group.2. Immune-Regulating EffectPoria water extract12g/kggiven to mice by gavage for 21 days can increase the number of peripheral T lymphocytes α-ANAE positive lymphocytes, enhance the proliferation response of splenic lymphocytes to ConA stimulation, increase the activity of IL-2 in the spleen of mice, and the activity of superoxide dismutase (SOD) in the liver of mice, inhibiting the generation of malondialdehyde (MDA), showing significant free radical scavenging effects. Poria water extract by gavage can significantly inhibit the 2,4-dinitrofluorobenzene-induced allergic contact dermatitis in mice, reducing ear swelling and ear tissue block weight, showing a certain dose-effect relationship. Mice given Poria polysaccharides200mg/kgby gavage for two weeks show significant improvement in cyclophosphamide-induced immune deficiency, increasing the proportion of CD3+cells in the Peyer’s patches, mesenteric lymph nodes, and spleen, and decreasing the proportion of CD19+cells, indicating that Poria polysaccharides have a regulatory effect on intestinal mucosal immunity.[3]In BALB/c mice immunized with ovalbumin5mg/kgby gavage for 1–3 weeks, starting one week before immunization with Poria polysaccharides200mg/kg, can significantly increase the secretion of ovalbumin-specific secretory immunoglobulin A (sIgA) in feces, and significantly increase the expression of co-stimulatory molecules CD80 and CD86 in the Peyer’s patches of the small intestine, indicating that Poria polysaccharides have a regulatory effect on intestinal sIgA secretion, related to its activation of Peyer’s patch B lymphocytes.[4]3. Anti-Transplant Rejection EffectPoria alcohol extract shows significant inhibition of acute rejection reaction in heart transplantation, with rats receiving Poria alcohol extract25mg/kgor50mg/kgby gavage showing significantly prolonged survival time of transplanted hearts, reduced pathological damage, and decreased levels of peripheral blood IL-2 and IFN-γ, as well as the percentages of CD3+, CD4+, and CD8+cells, and the CD4+/CD8+ratio decreased. Poria polysaccharides50mg/kggiven by gavage can significantly prolong the survival time of kidney transplant recipients in rats, significantly reduce pathological damage; peripheral blood IL-2, IFN-γ levels, and the percentages of CD4+and CD8+cells significantly decreased, indicating that Poria polysaccharides have a good inhibitory effect on acute rejection reactions in kidney transplantation.[5]4. Anti-Tumor EffectPoria contains various components with anti-tumor activity, including Poria polysaccharides, which not only have direct anti-tumor effects but also enhance the body’s immune function to exert anti-tumor effects. Poria polysaccharides50mg/kggiven every other day by intraperitoneal injection for 4 times can induce TNF, thus having a certain killing effect on tumor cells. Poria polysaccharides100mg/kgor150mg/kggiven by gavage to mice can significantly inhibit the growth of S180 and Ehrlich ascites carcinoma (EAC) tumors, reduce tumor weight, and significantly enhance the activity of NK cells in tumor-bearing mice. Derivatives of Poria polysaccharides also show good anti-tumor effects. Carboxymethyl Poria polysaccharides(CMP)25–500mg/kgintraperitoneally injected show an inhibition rate of75.5%–92.7%; CMP5–50mg/kgintravenously injected shows an inhibition rate of34.8%–61.0%; CMP25–100mg/kgintravenously injected shows an inhibition rate of20.1%–36.7%against H22 liver cancer in mice. Sulfated Poria polysaccharides show both killing and apoptosis-inducing effects on S180 tumor cells, with an inhibition rate of38.39%, and enhance the body’s immunity. Sulfated new Poria polysaccharides, while not enhancing the phagocytic function of mouse mononuclear macrophages, show significant anti-tumor effects. Poria polysaccharides also show anti-tumor metastasis effects, with Lewis lung cancer mice showing a significant reduction in the number of lung metastases after gavage of Poria polysaccharides(0.5mg/mouse).【5】5. Anti-Aging and Anti-Fatigue EffectsPoria water extract can increase the content of hydroxyproline in the skin. Elderly rats given Poria water extract2.4and8g/kgby gavage show significantly increased skin hydroxyproline content. Elderly rats given Poria polysaccharides12mg/kgby gavage for 10 consecutive days show significantly increased serum superoxide dismutase (T-SOD, CuSOD) activity and decreased malondialdehyde (MDA) content. Normal mice given Poria polysaccharides20and40mg/kgby gavage three times every 12 hours show significantly prolonged survival time in low-temperature swimming tests.6. Sedative, Hypnotic, and Memory Improvement EffectsPoria water decoction5.85g/kggiven by gavage for 7 consecutive days significantly increases the sleep rate of animals at subthreshold doses of pentobarbital sodium and prolongs the sleep time of mice at threshold doses of pentobarbital sodium.[7]; 42.8g/kggiven by gavage can significantly shorten the latency to reach the platform in the water maze experiment and reduce the activity of acetylcholinesterase in the brains of mice with memory impairment induced by scopolamine.[8]【7】7. Lipid-Lowering and Liver-Protective EffectsRats fed a high-fat diet and given Poria water decoction15gper kgdaily by gavage for 10 weeks, combined with aerobic exercise training, can significantly inhibit lipid abnormalities, reduce the degree of endothelial and vascular wall damage, and delay the development of atherosclerosis in rats.[9,10]Carboxymethyl Poria polysaccharides show antiviral effects on Hepatitis B virus-infected HepG2.2.15 cell lines, with half-maximal effective concentrations (IC)50of4.38and5.78mg/mlfor inhibiting HBsAg and HBeAg secretion, respectively. Using a carbon tetrachloride combined factor method to create a rat liver fibrosis model, gavage of carboxymethyl Poria polysaccharides40mg/ratonce daily for 2 weeks can significantly reduce the expression of TGF-β, caspase-3, type II collagen, and laminin in liver tissues; reduce the expression of Smad-3 in liver fibrosis rats and increase the expression of Smad-7, indicating significant anti-liver fibrosis effects.[11]Using carbon tetrachloride, high-fat low-protein diet, and alcohol to replicate a rat liver cirrhosis model, subcutaneous injection of Poria alcohol extract75mg/kgonce daily for 3 weeks can significantly reduce the degree of liver fibrosis and lower collagen content in the liver.8. Other Pharmacological Effects100% Poria extract filter paper shows inhibitory effects on Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa, anthrax bacillus, Escherichia coli, group A streptococcus, and group B streptococcus. Poria water extract can induce an increase in intracellular calcium ion concentration, with concentrations of Poria water extract at31–250mg/Linducing an increase in intracellular calcium ion concentration of9.9%–33.7%, increasing with the dosage. Poria has important effects on the function of mitochondria and microtubule structure in nerve cells, with Poria water extract10–20mg/Lincubated with cells for24hours significantly resisting the reduction of mitochondrial MTT reduction ability caused by sodium azide.9. Toxicological StudiesThe median lethal dose (LD50) of carboxymethyl Poria polysaccharides injected intravenously in mice is3.13g/kg±0.14g/kg, with symptoms of reduced activity, limb weakness, convulsions, and weak breathing before death, occurring within1–2days. Mice given carboxymethyl Poria polysaccharides15g/kgonce by gavage show no toxic reactions. Intravenous injection of carboxymethyl Poria polysaccharides157and313mg/kgonce daily for 3 months shows no significant toxic reactions. Pregnant rats injected intraperitoneally with carboxymethyl Poria polysaccharides from day 6 to 15 of pregnancy show no fetal malformations. The LD50of sulfated Poria polysaccharides is7.358g/kg, with a 95% confidence interval of7.358g/kg±0.894g/kg.Appendix:1. Poria Pi This product is the dried outer skin of Poria. Its nature and taste are sweet, bland, and neutral. It enters the Lung, Spleen, and Kidney meridians. Its function is to promote urination and reduce swelling. Used for edema and urinary difficulties. Dosage is15–30g.2. Fu Shen This product is the part of Poria that contains pine roots. Its nature and taste are sweet, bland, and neutral. It enters the Heart and Spleen meridians. Its function is to calm the mind and spirit. Used for anxiety, palpitations, and forgetfulness. Dosage is9–15g.【References】[1] Ning Kangjian, Yang Jingsong, Shi Pingping. Observation of the Diuretic Effect of Poria in Rabbits, Anhui University of Science and Technology Journal, 2012, 26(4): 1-3.[2] Tian Ting, Chen Hua, Yin Lu, et al. Diuretic Effects of Water and Ethanol Extracts of Poria and Identification of Active Components. Chinese Journal of Pharmacology and Toxicology, 2014, 28(1): 57-62.[3] Wang Qing, Hu Minghua, Dong Yan, et al. Effects of Poria Polysaccharides on CD3+ and CD19+ Cell Changes in Immune-Deficient Mice. Chinese Journal of Immunology, 2011, 27(3): 228-231.[4] Wang Qing, Hu Minghua, Dong Yan, et al. Effects of Poria Polysaccharides on the Expression of Secretory Immunoglobulin A, CD80, and CD86 in Mice. Chinese Journal of Experimental Formulas, 2011, 17(13): 127-129.[5] Ding Chenguang, Tian Puxun, Xue Wujun, et al. Experimental Study on the Prevention of Acute Rejection Reaction in Rat Kidney Transplantation by Poria Polysaccharides. Chinese Journal of Integrated Traditional and Western Medicine, 2010, 30(3): 308-311.[6] Zhang Mixia, Li Yiwen, Zhang Desheng, et al. Inhibitory Effects of Poria Polysaccharides on Spontaneous Lung Metastasis in Lewis Lung Cancer Mice and Mechanism Study. Modern Drugs and Clinics, 2013, 28(6): 842-846.[7] You Qiuyun, Wang Ping. Comparative Study on the Sedative and Hypnotic Effects of Poria and Fu Shen Water Decoction. Journal of Hubei University of Traditional Chinese Medicine, 2013, 15(2): 15-17.[8] Xu Yubin, Xu Zhilin, Li Mingyu, et al. Pharmacological Study of Poria and Its Chemical Components on Learning, Memory, and Sedative-Hypnotic Effects. Chinese Herbal Medicine, 2014, 45(11): 1577-1584.[9] Miao Hua, Zhang Xu. Effects of Poria Combined with Aerobic Exercise on Lipid Disorder Indicators Based on Metabolomics Characterization in Rats. Chinese Journal of Sports Medicine, 2013, 32(11): 1013-1017.[10] Li Ji, Wang Song. Effects of Poria Combined with Aerobic Exercise on the Progression of Atherosclerosis in Rats. Journal of Harbin Normal University Natural Science Edition, 2011, 27(6): 74-77.[11] Chen Jiyan. In Vivo and In Vitro Studies of Carboxymethyl Poria Polysaccharides Against Hepatitis B Virus. Chinese Journal of Biochemical Drugs, 2015, 35(2): 66-70.