Both Qing Re Jie Du Oral Liquid and Er Ding Granules are heat-clearing agents and can be used for sore throat caused by excessive heat and toxins, as well as acne. However, what are the differences between them aside from their similarities?
Comparison of Formulations
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Composition of Er Ding Granules: Zihua Diding (Viola yedoensis), Pugongying (Dandelion), Banbianlian (Lobelia), Banlan Gen (Isatis root)
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Composition of Qing Re Jie Du Oral Liquid: Shigao (Gypsum), Jinyinhua (Honeysuckle), Xuan Shen (Scrophularia), Dihuang (Rehmannia), Lianqiao (Forsythia), Zhi Zi (Gardenia), Tian Diding (Sweet Violet), Huangqin (Scutellaria), Long Dan (Gentiana), Banlan Gen (Isatis root), Zhi Mu (Anemarrhena), Mai Dong (Ophiopogon)
Analysis
In terms of formulation, Er Ding Granules consist of four heat-clearing and detoxifying herbs, including Zihua Diding, which is essential for treating carbuncles, and Pugongying, commonly used for internal and external abscesses caused by heat toxins. In contrast, the main herbs in Qing Re Jie Du Oral Liquid are Jinyinhua, which is sweet and cold, and Lianqiao, which is bitter and cold, along with additional herbs like Mai Dong, Xuan Shen, and Dihuang that nourish yin, clear heat, cool the blood, and detoxify. These effects are not present in Er Ding Granules.
Comparison of Efficacy and Applicable Populations
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Er Ding Granules are a heat-clearing and detoxifying agent, effective for conditions caused by excessive heat toxins, such as sore throat, carbuncles, and wind-heat eye infections.
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Qing Re Jie Du Oral Liquid is a heat-clearing agent used for symptoms caused by heat toxins, such as fever, irritability, thirst, and sore throat; it is suitable for flu and upper respiratory infections presenting with these symptoms.
Analysis
Similarities:
Both Er Ding Granules and Qing Re Jie Du Oral Liquid are bitter and cold, and can be used for sore throat and acne caused by excessive heat toxins.
Differences:
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When using Er Ding Granules for wind-heat eye infections, it can be combined with Long Dan Xie Gan Wan (Gentiana Liver-Drain Pill) for liver fire, or with Song Ju Gan Mao Pian (Sang Ju Cold Remedy) and Banlan Gen Granules for wind-heat invasion. (Small formula preparations are not only specific in efficacy but also convenient for physicians to choose in clinical practice.)
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Qing Re Jie Du Oral Liquid, compared to Er Ding Granules, includes the sweet and cold Jinyinhua, the bitter and cold Lianqiao, and additional herbs that nourish yin, cool the blood, and provide moisture. In contrast to localized discomfort from sore throat, wind-heat eye infections, and acne, flu and upper respiratory infections often present with systemic discomfort. Qing Re Jie Du Oral Liquid not only requires herbs targeting wind-heat invasion but also needs to protect yin fluids to prevent the heat from damaging yin and fluids. (The formulation is more comprehensive, considering a wider variety of herbs, which is an advantage in treating complex conditions in clinical practice.)
When recommending to customers, one can suggest small formula preparations or large formula preparations based on the simplicity or complexity of their symptoms. Additionally, depending on the severity of their condition, one can recommend either the standalone use of small formula preparations or the combination with other related medications.
Comparison of Clinical Applications
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Both Er Ding Granules and Qing Re Jie Du Oral Liquid are bitter and cold, and are not suitable for wind-cold colds or those without heat symptoms.
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Bitter and cold herbs can easily damage the body’s yang energy, so they should not be taken for long periods. For individuals with a tendency towards deficiency and cold, caution is advised.
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For those with dry mouth and throat due to yin deficiency, heat-clearing agents should not be chosen; instead, yin-nourishing formulas such as Bai He Guo Jin Wan (Lily Bulb Solid Gold Pill) or Yang Yin Qing Fei Gao (Nourishing Yin and Clearing Lung Paste) should be selected.
(This content is for professional reference only; medications should be purchased and used according to the instructions or under the guidance of a pharmacist.)
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