Influenza is an acute respiratory infectious disease caused by the influenza virus. The virus exists in the respiratory tract of infected individuals and is transmitted to others through droplets when the patient coughs or sneezes. Influenza is highly contagious, and due to the virus’s tendency to mutate, even individuals who have previously had influenza can become infected again during subsequent outbreaks. Therefore, influenza can easily lead to epidemic outbreaks. Generally, the chances of outbreaks are higher in winter and spring, with 20-40% of the population potentially infected each time. The symptoms of simple influenza include sudden chills, fever, headache, body aches, nasal congestion, runny nose, dry cough, chest pain, nausea, and loss of appetite. Infants or the elderly may develop complications such as pneumonia or heart failure.
Chinese Pharmacopoeia 2020 Edition Volume 1
Qingkailing Keli
Qingkailing Granules
【Formula】Bile acid 13g, Mother of Pearl 200g, Deoxycholic acid 15g, Gardenia 100g, Water buffalo horn 100g, Isatis root 800g, Baicalin 20g, Honeysuckle 240g.
【Preparation Method】
(1) The above eight ingredients, Isatis root and Gardenia are decocted in water twice, the first time for 1.5 hours and the second time for 1 hour. The decoctions are combined, filtered, and the filtrate is concentrated to a relative density of 1.12-1.16 (at 80°C). Ethanol is added to achieve a concentration of 60%, allowed to stand for 24 hours, filtered, and the ethanol is recovered from the filtrate, concentrated, and dried. Honeysuckle is soaked in water for half an hour, then decocted twice in water for 1.5 hours each time. The decoctions are combined, filtered, and concentrated to a relative density of 1.20-1.25 (at 80°C). Ethanol is added to achieve a concentration of 60%, allowed to stand for 24 hours, filtered, and the ethanol is recovered, concentrated, and dried. Water buffalo horn is powdered and boiled in 4mol/L barium hydroxide solution for 7 hours, then filtered while hot. Mother of Pearl is added to 4mol/L sulfuric acid solution and boiled for 7 hours, then filtered while hot. The cooled filtrate is combined with the water buffalo horn filtrate, filtered, and concentrated to 2-3 times the original amount, cooled, and ethanol is added to achieve a concentration of 60%, mixed, allowed to stand for 24 hours, filtered, and the ethanol is recovered. The pH is adjusted to 7 with 20% sodium hydroxide solution, refrigerated, filtered, and the filtrate is concentrated to a relative density of 1.36-1.40 (at 60°C), encapsulated with beta-cyclodextrin, and dried to obtain the encapsulated powder of water buffalo horn and Mother of Pearl. Deoxycholic acid and bile acid are dissolved in an appropriate amount of ethanol, filtered, and the filtrate is either used directly or mixed with orange oil essence [Specification (2)], encapsulated with beta-cyclodextrin, and dried to obtain the encapsulated powder of bile acid and deoxycholic acid. The powdered extracts of Isatis root and Gardenia, powdered extracts of Honeysuckle, Baicalin, and the two encapsulated powders are mixed with an appropriate amount of mannitol, dextrin, and sweeteners, granulated, dried, and produced into 1500g [Specification (1)]; or the powdered extracts of Isatis root and Gardenia, powdered extracts of Honeysuckle, Baicalin, and the two encapsulated powders are mixed with an appropriate amount of sucrose and dextrin, granulated, dried, and produced into 3000g [Specification (2)], thus obtained.
(2) The above eight ingredients, Baicalin is ground into fine powder; water buffalo horn and Mother of Pearl are powdered and made into hydrolysates; Deoxycholic acid and bile acid are dissolved in alkaline aqueous solution, mixed with beta-cyclodextrin for encapsulation; the remaining ingredients including Gardenia are decocted twice in water, the decoction is filtered, combined with the above hydrolysate and bile acid solution, mixed, concentrated, and combined with powdered sucrose and fine Baicalin powder, dried, and granulated to produce 3000g [Specification (2)]; or mixed and granulated, dried, and produced into 10000g [Specification (3)], thus obtained.
【Properties】This product is a light yellow or yellow-brown to brown granule; it has a sweet and slightly bitter taste.
【Functions and Indications】Clears heat and detoxifies, calms the mind and soothes the spirit. It is used for high fever that does not subside, restlessness, sore throat, red tongue, yellow coating, and rapid pulse caused by external wind-heat, or internal fire toxin; upper respiratory tract infections, viral influenza, acute purulent tonsillitis, acute pharyngitis, acute bronchitis, high fever, etc., that fall under the above syndromes.
【Dosage and Administration】Oral administration. 1-2 bags at a time, 2-3 times a day. Dosage for children should be reduced, or as directed by a physician.
【Precautions】Use with caution in patients with chronic illness and weakness if diarrhea occurs.
【Specifications】(1) Each bag contains 1.5g (including Baicalin 20mg, no sucrose)
(2) Each bag contains 3g (including Baicalin 20mg; orange flavor)
(3) Each bag contains 10g (including Baicalin 20mg)
【Storage】Sealed.
【Formula Explanation】
Qingkailing is a modified preparation developed based on the An Gong Niu Huang Wan, one of the three treasures of modern warm disease theory: based on the analysis of the component drugs, it replaces the rare cow bile with its main effective components, bile acid and deoxycholic acid; replaces the expensive rhinoceros horn and pearl with water buffalo horn and Mother of Pearl, which have similar effective components; replaces the weakened antibacterial action of Huanglian due to amino acid antagonism with Isatis root to enhance the heat-clearing and detoxifying effects, and removes heavy metal drugs such as cinnabar, realgar, and gold foil. In the formula, bile acid and deoxycholic acid clear heat and detoxify, resolve phlegm and open the orifices, cool the liver and extinguish wind; Baicalin clears heat and detoxifies; water buffalo horn, Honeysuckle, Gardenia, and Isatis root work together to clear heat, drain fire, and cool the blood to detoxify; Mother of Pearl calms the liver and subdues yang, tranquilizes the mind and soothes the spirit. The combination of these herbs works together to achieve the effects of clearing heat and detoxifying, calming the mind and soothing the spirit.
【Clinical Applications】
1. Cold: Fever caused by external wind-heat evil, slight aversion to wind, or high fever that does not subside, restlessness, cough with yellow phlegm, sore throat, constipation, short and red urine, red tongue with yellow coating, and rapid pulse; upper respiratory tract infections with the above symptoms.
2. Rib Pain: Caused by damp-heat obstruction leading to loss of appetite, abdominal distension, rib pain, bitter mouth, nausea, short and red urine, irregular bowel movements, or jaundice, red tongue with yellow greasy coating, and wiry slippery rapid pulse; viral hepatitis with the above symptoms.
【Pharmacology and Toxicology】
This product has antipyretic, choleretic, anti-inflammatory, and antibacterial effects.
1. Antipyretic: Qingkailing Granules and Qingkailing Droplets can lower the body temperature of rabbits caused by intravenous injection of typhoid, paratyphoid A and B trivalent bacterial vaccines.
2. Choleretic: Qingkailing Granules can increase bile secretion in guinea pigs.
3. Anti-inflammatory: Qingkailing Granules can reduce gallbladder mucosal edema, papillary hyperplasia, and inflammatory cell infiltration in guinea pigs with experimental cholecystitis induced by lincomycin.
4. Antibacterial: This product has inhibitory effects in vitro on Staphylococcus aureus, Escherichia coli, and clinically isolated strains of Staphylococcus aureus, Escherichia coli, Streptococcus pneumoniae, and beta-hemolytic streptococcus; in vivo, it protects mice infected with Staphylococcus aureus and Klebsiella pneumoniae, reducing mortality and prolonging survival time.
5. Others: Qingkailing Droplets and Granules can reduce the incidence of electrical seizures in mice and enhance their tolerance to hypoxia under normal pressure.
6. Toxicology: The LD50 of Qingkailing Capsules in mice is 112g (raw drug)/kg. The LD50 of Qingkailing Granules in mice is 57.8g/kg.
Extracted from the CCTV Health Road program
【Instructions】
【Drug Name】Generic Name: Qingkailing Granules
【Ingredients】Bile acid, Mother of Pearl, Deoxycholic acid, Gardenia, Water buffalo horn, Isatis root, Baicalin, Honeysuckle. Excipients include sucrose and beta-cyclodextrin.
【Properties】This product is a light yellow or yellow-brown to brown granule; it has a sweet and slightly bitter taste.
【Indications】Clears heat and detoxifies, calms the mind and soothes the spirit. It is used for fever, restlessness, and sore throat caused by external wind-heat; and for upper respiratory tract infections, viral influenza, acute pharyngitis with the above symptoms.
【Specifications】Each bag contains 3g, 10g (including Baicalin 20mg)
【Dosage and Administration】Oral, 1-2 bags at a time, 2-3 times a day.
【Adverse Reactions】Not yet clear.
【Contraindications】Not for use in pregnant women; contraindicated for diabetic patients.
【Precautions】
1. Avoid smoking, alcohol, and spicy, cold, and greasy foods.
2. Do not take nourishing TCM during the medication period.
3. Not suitable for those with wind-cold flu, characterized by severe chills, mild fever, no sweating, headache, nasal congestion, runny clear mucus, and itchy cough.
4. Use with caution in patients with hypertension and heart disease; patients with chronic weakness and diarrhea should use with caution.
5. Those with severe chronic diseases such as liver disease and kidney disease should take under the guidance of a physician.
6. If symptoms do not improve after 3 days of use, seek medical attention.
7. Children and the elderly should use under the guidance of a physician.
8. Those allergic to this product should not use it; those with allergic tendencies should use with caution.
9. Do not use if the product’s properties have changed.
10. Children must use under adult supervision.
11. Keep this product out of reach of children.
12. If using other medications, consult a physician or pharmacist before using this product.
【Drug Interactions】Consult a physician or pharmacist for details on potential drug interactions when used with other medications.
【Storage】Sealed.
【Packaging】① Composite film bag. Each small bag contains 10 grams, each medium bag contains 10 small bags.② Composite film bag. Each small bag contains 10 grams, each medium bag contains 20 small bags.③ Composite film bag. Each small bag contains 10 grams, each medium box contains 10 small bags.④ Composite film bag. Each small bag contains 10 grams, each medium box contains 20 small bags.
【Shelf Life】24 months.
【Standards】Chinese Pharmacopoeia 2020 Edition
【Approval Number】National Drug Approval NumberZ10950088
【Manufacturer】Guangzhou Baiyunshan Mingxing Pharmaceutical Co., Ltd.
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