Qingre Jiedu Oral Liquid is a heat-clearing and detoxifying agent. It is used for symptoms caused by excessive heat toxin, such as fever, red face, irritability, thirst, and sore throat; it is indicated for influenza and upper respiratory infections presenting with the aforementioned symptoms.Pharmacological Effects of Nanyang Qingre Jiedu Oral LiquidThis formula is included in the 2010 edition of the “Chinese Pharmacopoeia” and is a commonly used traditional Chinese medicine for treating influenza, classified as a non-prescription Class B preparation, with heat-clearing and detoxifying effects. Clinical studies on the treatment of excess heat syndrome indicate its efficacy against infectious diseases in modern medicine, such as viral hepatitis, lobar pneumonia, and acute appendicitis. Modern pharmacology has confirmed that heat-clearing and detoxifying medicines possess antiviral, antibacterial, detoxifying, anti-inflammatory, and immune-regulating properties, particularly notable antiviral effects. Existing literature shows that Qingre Jiedu Oral Liquid has a certain inhibitory effect on various bacteria, including Staphylococcus aureus, Streptococcus pneumoniae, Salmonella, and Escherichia coli, especially strong against common bacteria in respiratory infections.Analysis of the Formula of Nanyang Qingre Jiedu Oral LiquidFormula analysis and explanation
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Chief Herbs: Jin Yin Hua (Honeysuckle), Lian Qiao (Forsythia)
Jin Yin Hua is sweet and cold, dispersing and penetrating; Lian Qiao is bitter and cold, clearing and resolving.
The two herbs complement each other, dispersing wind-heat and strongly clearing heat and detoxifying, suitable for exogenous heat diseases, regardless of whether the pathogen is in the Wei, Qi, Ying, or Blood levels, hence they are the chief herbs.
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Deputy Herbs: Shi Gao (Gypsum), Zhi Mu (Anemarrhena), Zhi Zi (Gardenia), Huang Qin (Scutellaria), Long Dan Cao (Gentiana), Ban Lan Gen (Isatis), Lian Qiao (Forsythia), Di Ding (Viola)
Shi Gao is acrid, sweet, and very cold, effectively clearing heat and draining fire, alleviating irritability and thirst;
Zhi Mu is bitter and sweet, clearing and draining, nourishing Yin and moistening dryness;
Huang Qin is bitter and cold, effectively clearing heat and drying dampness, draining fire and detoxifying;
Zhi Zi is bitter and cold, effectively draining fire and alleviating irritability, clearing heat and promoting urination;
Di Ding is bitter and cold, effectively clearing heat and detoxifying;
Long Dan Cao is bitter and cold, effectively clearing liver and gallbladder fire;
Ban Lan Gen is bitter and cold, clearing heat, draining fire, and cooling blood to detoxify.
The seven herbs work together to assist the chief herbs in clearing heat and detoxifying, thus they are the deputy herbs.
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Assistant Herbs: Mai Dong (Ophiopogon), Xuan Shen (Scrophularia), Di Huang (Rehmannia)
Mai Dong is sweet, moist, slightly bitter, and slightly cold, effectively clearing heat, nourishing Yin, calming the heart, and alleviating irritability;
Di Huang is sweet, moist, bitter, and cold, effectively clearing heat, cooling blood, nourishing Yin, and generating fluids;
Xuan Shen is bitter, sweet, salty, and cold, effectively clearing heat, cooling blood, nourishing Yin, and lowering fire.
The three herbs work together to assist the chief and deputy herbs in clearing heat, draining fire, cooling blood, and detoxifying, while also protecting Yin fluids to prevent damage from heat pathogens, thus they are collectively the assistant herbs.
The entire formula is characterized by its bitter and cold properties, combined with sweet and cold elements, effectively achieving the function of clearing heat and detoxifying, thus it is good for treating fever, red face, irritability, thirst, and sore throat caused by excessive heat toxin; it can also be used for influenza and upper respiratory infections presenting with the aforementioned symptoms.
Combined Use of Nanyang Qingre Jiedu Oral Liquid
Nanyang Qingre Jiedu Oral Liquid has antipyretic, antibacterial, anti-inflammatory, antiviral, and immune-boosting effects. Clinically, it is used for influenza, upper respiratory infections, acne, and hand-foot-mouth disease in children with excessive heat toxin.
Viral infections
Example combinations: Moroxydine hydrochloride tablets + Qingre Jiedu Oral Liquid + Kexing Ling capsules + Ambroxol hydrochloride oral solution + Watermelon frost lozenges (Watermelon frost spray, Jin Sang Zi, Huang’s throat lozenges, etc.) + Nebulization therapy (especially for children)
Bacterial infections
Example combinations: Choose appropriate antibiotics based on test results, such as Roxithromycin, Cephalexin, Azithromycin, etc. + Qingre Jiedu Oral Liquid + Kexing Ling capsules/Phlegm-clearing tablets/Ambroxol hydrochloride oral solution + lozenges
For severe nasal congestion, a saline nasal mucosa cleaning device can be used to relieve nasal congestion (not exceeding 20 mg daily (about 1/4 tube) is the principle, with 2-3 drops per nostril at intervals of 2-3 hours).
For patients with upper respiratory infections with severe fever and headache symptoms
Example combinations:Paracetamol tablets (for children, consider children’s paracetamol granules, Chen Gong Zai Xin, etc.) + Qingre Jiedu Oral Liquid + Kexing Ling capsules/Phlegm-clearing tablets/Ambroxol hydrochloride oral solution + traditional Chinese medicine lozenges/aerosols + nebulization therapy (for children)
Acne
Example combinations: Internal use of heat-clearing and detoxifying traditional Chinese medicine (Qingre Jiedu Oral Liquid, Dang Gui Ku Shen Wan, or Lian Qiao Bai Du Wan, etc.) + external use of wound healing agents (such as Zi Cao ointment, detoxifying and healing powder, or Qing tea poultice with Ruyi Jin Huang powder, etc.)
Hand-foot-mouth disease in children
Symptomatic treatment; those with excessive heat toxin can take antiviral medications and heat-clearing and detoxifying herbal medicines such as Qingre Jiedu Oral Liquid, and supplement vitamins B, C, etc. During treatment, ensure isolation, oral care, and hygiene; trim the baby’s nails, and if necessary, wrap the baby’s hands to prevent scratching the rash.
Advantages of Nanyang Qingre Jiedu Oral Liquid
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Observation — Observe the color; Nanyang Qingre Jiedu Oral Liquid has a deep color, resembling ink, clear and bright.
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Smell — Smell the aroma; Nanyang Qingre Jiedu Oral Liquid has a rich traditional Chinese medicine fragrance, refreshing and pleasant.
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Taste — Taste the flavor; Nanyang Qingre Jiedu Oral Liquid has the characteristic bitterness of traditional Chinese medicine, slightly sweet after bitterness.
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Testing — Content determination (2015 edition of the Chinese Pharmacopoeia), determined by high-performance liquid chromatography (Appendix VI D).
Chromatographic conditions and system suitability tests use octadecylsilane-bonded silica gel as the filler; methanol-water-phosphoric acid (50:50:0.3) as the mobile phase; detection wavelength at 276 nm. The theoretical plate number calculated based on the peak of baicalin should not be less than 1000. Preparation of the reference solution: Accurately weigh the baicalin reference substance dried under reduced pressure at 100°C to constant weight, and dissolve in ethanol to prepare a solution containing 0.01 mg per 1 ml as the reference solution. Preparation of the test solution: Accurately measure 2 ml of the product under test, place it in a 100 ml volumetric flask, add an appropriate amount of ethanol, shake, dilute to the mark with ethanol, mix well, let it stand, filter, and take the filtrate as the test solution. Measurement method: Accurately take 10 μl of both the reference solution and the test solution, inject into the liquid chromatography instrument, and measure to obtain the results. Each bottle of this product contains baicalin (C21H18O11) not less than 10.0 mg.
Precautions for Nanyang Qingre Jiedu Oral Liquid
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Not suitable for those with wind-cold colds.
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Avoid smoking, alcohol, and spicy, cold, greasy foods. It is not advisable to take nourishing traditional Chinese medicines simultaneously during the medication period.
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Children, pregnant women, nursing mothers, the elderly, and those with weak spleens and loose stools should take it under the guidance of a physician. Diabetic patients and those with severe chronic diseases such as hypertension, heart disease, liver disease, and kidney disease should also take it under the guidance of a physician.
When selecting heat-clearing and detoxifying medications, it is important to understand whether there are heat symptoms, such as fever, red face, irritability, thirst, sore throat, and whether facial acne presents with redness, swelling, and pain. Only after confirming the presence of heat symptoms should their use be recommended.
